Toll-like receptor (TLR)-9 genetics and function in sarcoidosis
نویسندگان
چکیده
منابع مشابه
The significance of Toll-like receptor (TLR) 2 and 9 gene polymorphisms in psoriasis
Address for correspondence: Michał Sobjanek MD, PhD, Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 1a Kliniczna St, 80-402 Gdansk, Poland, phone: +48 607 039 729, e-mail: [email protected] Received: 8.01.2016, accepted: 20.04.2016. The ethiopathogenesis of psoriasis is complex, multifactorial and still not well understood. Nowadays, the systemic, inflammator...
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Is there an association between impaired pulmonary function and mortality in never smokers? I read with great interest the article by Mannino et al 1 on the association between impaired pulmonary function and mortality, and wish to comment on two statements in the paper. Firstly, the authors report that ''an interesting finding in (their) analysis was that, in never smokers, moderate or severe ...
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Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system. DNA recognition via TLR9 results in an inflammatory reaction, which eventually also activates a Th1-biased adaptive immune attack. In addition to cells of the immune system, TLR9 mRNA and protein are also widely expressed in breast cancer cell lines and in clinical breast cancer specimens. Although synthetic TLR...
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OBJECTIVE Individuals with type 2 diabetes have a myriad of metabolic aberrations including increased inflammation, increasing their cardiovascular risk. Toll-like receptors (TLRs) and their ligands play a key role in insulin resistance and atherosclerosis. However, there is a paucity of data examining the expression and activity of TLRs in type 2 diabetes. Thus, in the present study, we examin...
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Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor (TLR) family have been shown to be involved in recognition of the etiologic organism Plasmodium falciparum: The glycosylphosphatidylinisitol anchor induces signaling in host cells via TLR-2 and -4, w...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2010
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2010.04205.x